|
KMID : 0438219750120020481
|
|
Korea University Medical Journal
1975 Volume.12 No. 2 p.481 ~ p.486
|
|
|
Influence of Iproniazid and Pyrogallol on the Catecholamine Liberation of Reserpine in Brain and Heart
|
|
|
|
|
Abstract
|
|
|
It is well known that catecholamines are usually metabolized by monoamine oxidase (MAO) and catechol-o-methyltransferase (COMT). It was postulated that iproniazid is MAO inhibitor and pyrogallol is a COMT inhibitor. Reserpine release the catecholamine from sympathetic innervated organ in small dose and deplete it in large dose. In this paper, the influence of iproniazid and pyrogallol on the reserpine induced catecholamine liberation in brain and myocardium of rabbits were studied.
The results were obtained as follows;
1. Catecholamine contents in brain and myocardium were increased by iproniazid injection and decreased by pyrogallol.
2. The decreased catecholamine contents induced by reserpine in brain and myocardium were significantly increased by iproniazid pretreatment and tended to increase by pyrogallol pretreatment. These findings were suggested that MAO is a major enzyme for the catecholamine metabolism in brain and myocardium.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|